Acetylcysteine (ACC) was chosen as comparator drug (common mono preparations). Totally, 25 physicians were recruited in Switzerland who participated with 139 patients. Introduction. In some studies, patients were requested to fill out diaries with daily assessments of, e.g., cough frequency, expectoration, and breathlessness. – Non GMO Sustainably Sourced Vegetarian, Zarbee's Naturals Baby Cough Syrup with Agave & Thyme, Natural Cherry Flavor, 2 Ounce Bottle, Robitussin Naturals Cough Relief & Immune Health Syrup 8.3oz with Honey, Ivy Leaf & Zinc. The first patient was recruited in January 2017, and the last visit of the last patient was in March 2018. Active ingredient: Each 5 ml of syrup contains 35 mg of extract (as dry extract) from ivy leaf (Hedera helix L.) (5 - 7.5 : 1). There were 4 different consent forms used in the study depending on the age of the subjects: one consent form for adult subjects, one form for subjects ranging between 14 and 18 years old (signed by the subjects), one form for subjects between ages 11 and 13 years who can already read the document by themselves (signed by the parents), and one form for parents of subjects between 6 and 11 years (signed by parents). Liver disorders. Coferb Cough Syrup. The main components of ivy leaf that give it its health benefits are called saponins. Botanical names: Hedera helix How It Works Although ivy's composition has not been subject to detailed scientific investigations, it is known to contain 5–8% saponins. This medicine is available without prescription. containing ivy leaf extract. Nat Med 1999;14:28–33. Within the 139 included patients, only 21 patients were prescribed an acetylcysteine preparation resulting in an unequal group distribution. Viral infection-caused acute bronchitis was the most common disease at entry visit with 53.4% in the EA 575® group and 57.1% in the ACC group, followed by other acute inflammation of the respiratory diseases with 25.4% in the EA 575® group and 33.3% in the ACC group. Compared with the conventional quality control method that measures the contents of hederacoside C in ivy leaf extracts, the newly developed method can provide more information about the chemical composition of ivy leaf extracts. Formulations similar to Coferb have been recognized by international clinical trials endorsing safety and efficacy of the product. [12] in children and adults. Cough syrup (Prospan; Panoto-s; Athos; Abrilar) containing English ivy leaf extract is POSSIBLY SAFE when taken by mouth three times daily for 1 week. The current noninterventional study was performed in 118 patients using EA 575® and 21 patients using ACC for the treatment of acute bronchitis. Maty's Organic Children's Mucus Cough Syrup, Made with Organic Honey, Thyme & Ginger - 6 fl oz. Ivy leaves (hederae helicis folium) exert an expectorant and antispasmodic action on the respiratory tract [1]. Other characteristic symptoms include sputum production, shortness of breath, and wheezing related to the obstruction of the inflamed airways. Further, the patients were asked to keep a diary during the course of treatment, which includes following symptoms: number of coughing fits during daytime, coughing intensity, chest pain during coughing, dyspnoea during coughing, possibility to cough-up mucus, cough-related sleep disturbances, frequency of wake ups at night, and general well-being. Zarbee's Naturals Children's All in One Nighttime Cough Syrup + Mucus, Throat & Nasal, Natural Grape Flavor, 4 Ounce, Prospan Cough Syrup - 100ml CHESTY Cough Relief & Mucus Relief. At entry visit, all clinical assessments including coughing fits, sputum, dyspnoea, rales, severity of the diseases, and coughing quality were rated with moderate intensity in both groups. There was a significant improvement in the reduction of both groups from baseline to end visit. In summary, the study showed that both preparations are effective and safe in the treatment of bronchitis. At the beginning, BSS average was 6.5 points in the EA 575® group and 6.7 points in the group of ACC patients, respectively, showing a moderate impairment for both. PROSPAN ® Cough Syrup with ivy leaf offers reliable help with the excessive formation of thick mucous and coughs associated with colds.. An exclusive extraction method and absolute precision in production ensure the quality of the dried ivy leaf extract that makes PROSPAN® such an effective and safe remedy. Diseases with the leading symptom “cough” are economically relevant as respiratory diseases are the most common reason for working incapacity and affect the quality of patient’s life [2]. Data from a large clinical trial revealed that the median duration of cough from acute bronchitis due to all causes was 18 days [2]. In addition, approximately 50% of patients with acute bronchitis report the production of purulent sputum [2]. ENGELHARD Arzneimittel GmbH & Co. KG Herzbergstraße 3, 61138 Niederdorfelden, Germany Module 1 Common Technical Document Prospan Syrup THR 35693/0001 Material and Methods. The stimulation of β2-AR provides an increased surfactant production which leads to the liquefaction of the mucus. Material and Methods. Büechi S, Vögelin R, von Eiff MM, Ramos M, Melzer J. EA 575® is effectively independent of the indication or concomitant disease. In the current study design (noninterventional study), the physicians were totally free in their prescription decision. With regard to duration of symptoms, no significant differences were observed between the treatment groups. All symptoms showed a comparable improvement in the reduction of both groups from baseline to end visit. Prospan Chesty Cough Relief - Prospan Australia - Prospan … Criteria for exclusion of the documentation were as follows: known hypersensitivity to the active ingredients, treatment with the medications in the last two weeks before study entry, participation in another trial in the same time, and legal incapacity. A previous multicenter study showed that EA 575® exerts mucolytic action equal to acetylcysteine but with better tolerability [23]. It is important to note that the decision to treat the patient with either EA 575® or an ACC mono preparation was made before it was decided to include the patient into the noninterventional study. The validated method was successfully applied to quantify all six compounds in a 30% ethanol ivy leaf extract and 13 ivy leaf extract products. Hecker M. Efficacy and tolerance of Ivy extract (Prospan®) in patients suffering from respiratory tract diseases. More Buying Choices. Syrup: for children up to 12 years, 5 ml, three times daily, and for 12 years and older and adults, 10 ml, three times daily. Prime members enjoy FREE Delivery and exclusive access to music, movies, TV shows, original audio series, and Kindle books. Most studies were conducted with preparations containing the ivy leaf dry extract EA575® as active ingredient [12]. Zarbee'S Natura Children's Grape Flavor Cough Syrup + Mucus, 2 Ounce, Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 fl oz- Helps Maintain Respiratory and Bronchial Health, Supports Healthy Mucous Membranes, Effective for Adults and Children | Pack of 3, Vicks Children's Botanicals, Day & Night Twin Pack, Elderberry Syrup to Soothe Nasal Irritation, Marshmallow Root to Soothe Cough, Ivy Leaf to Help Clear Mucus, Drug-Free 4 FL OZ Day/4 FL OZ Night, Mommy's Bliss Organic Kids Cough Syrup + Immunity Support - 4 fl oz, Nature's Life English Ivy Extract | Helps Support Respiratory & Bronchial Health | 136mg of Hedera Helix Leaf Extract (English Ivy), Vegetarian | 90ct, Zarbee's Naturals Children's Cough Syrup + Mucus with Dark Honey & Ivy Leaf, Natural Grape Flavor, 4 oz Bottles (Pack of 2), Children's Robitussin Naturals Cough Relief Honey & Ivy Leaf Syrup 8.3 oz, Zarbee's Naturals Cough & Throat Relief + Mucus Daytime Drink Mix with Dark Honey, Natural Lemon Flavor, 6 Packets, FREE 2-hour delivery on orders over $35 with Prime. Subsequently, treatments were prescribed by the doctor. This leads to relaxation in the bronchial muscles and plausibly explains the bronchospasmolytic effect of ivy [24]. Effect or tolerability data was compared by repeated general linear model analysis using data from entry and final visits as intrasubject variables, treatment as between subject factor, and sex and child/adults as covariates. Our cough syrup works as a bronchodilator and an expectorant which eases chest congestion, inflammation of the trachea and soothes sore throat. In the ACC group, 21 × 7.48 = 157 patient days were calculated together across all dosage forms. We start with our proprietary Dark Honey Blend and add English Ivy Leaf extract and Marshmallow Root Extract to soothe irritated throats and help your child clear mucus when they are coughing. Over the entire treatment period, there was a reduction to 1.8 points in the EA 575® group and to 2.1 points in the ACC groups corresponding to a low impairment in both groups and showing a comparable continuous improvement in both groups. Hedera helix preparations (ivy leaf extracts) are worldwide marketed for the treatment of different diseases of the respiratory tract system and include catarrh of the respiratory passages; symptomatic treatment of chronic inflammatory bronchial illnesses; and acute inflammations of the respiratory tract accompanied by coughing (HMPC Assessment) [1]. In fact, a 2012 study involving 268 children, 0 to 12 years old, discovered that 14 days of treatment with ivy leaf extract (in the form of a cough syrup) was a safe and effective treatment for children with a cough. Description. Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 fl oz- Helps Maintain Respiratory and Bro… An interim analysis, which was performed 15 months after study start, showed that data of the collected 139 patients were sufficient for an explorative analysis with the group comparison. These components are supportive of healthy mucous membranes and defend against occasional irritation of the lung and bronchial passages. Furthermore bronchial muscle cells reduce under β2-stimulating conditions the intracellular Ca2+ level. The data used to support the findings of this study are available from the corresponding author upon request. Ivy Syrup IVY LEAF EXTRACT 50 mg Read all of this leaflet carefully because it contains important information for you. 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